![Ο χρήστης Dr. Antonio Calles 🫁🚭 στο Twitter: "Final OS analysis from FLAURA trial. 🤫 Don't tell @EMA_News Exon21 L858R EGFR mutation doesn't show overall survival benefit from osimertinib. #ESMO19 #LCSM https://t.co/Bp5fg54iTt" / Ο χρήστης Dr. Antonio Calles 🫁🚭 στο Twitter: "Final OS analysis from FLAURA trial. 🤫 Don't tell @EMA_News Exon21 L858R EGFR mutation doesn't show overall survival benefit from osimertinib. #ESMO19 #LCSM https://t.co/Bp5fg54iTt" /](https://pbs.twimg.com/media/EFkKHsyWkAEaQ92.jpg:large)
Ο χρήστης Dr. Antonio Calles 🫁🚭 στο Twitter: "Final OS analysis from FLAURA trial. 🤫 Don't tell @EMA_News Exon21 L858R EGFR mutation doesn't show overall survival benefit from osimertinib. #ESMO19 #LCSM https://t.co/Bp5fg54iTt" /
Javier de Castro on Twitter: "Impressive results in FLAURA study. PFS 18,9 m, HR 0,46, in pt CNS mets 15,9, and positive trend in OS. Osimertinib best EGFR TKI ever seen https://t.co/YmSu5gciOO" /
![FLAURA Trial: Survival Benefit Confirmed for Tyrosine Kinase Inhibitor in EGFR Mutation-Positive Advanced NSCLC - The Medical Xchange FLAURA Trial: Survival Benefit Confirmed for Tyrosine Kinase Inhibitor in EGFR Mutation-Positive Advanced NSCLC - The Medical Xchange](https://themedicalxchange.com/wp-content/uploads/2019/10/2408_ESMO_2019_NSCLC_Fig_1.png)
FLAURA Trial: Survival Benefit Confirmed for Tyrosine Kinase Inhibitor in EGFR Mutation-Positive Advanced NSCLC - The Medical Xchange
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Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study | SpringerLink
![First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) | Scientific Reports First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) | Scientific Reports](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41598-021-02561-z/MediaObjects/41598_2021_2561_Fig2_HTML.png)
First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) | Scientific Reports
![Osimertinib versus Standard of Care EGFR TKI as First-Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA Asian Subset - Journal of Thoracic Oncology Osimertinib versus Standard of Care EGFR TKI as First-Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA Asian Subset - Journal of Thoracic Oncology](https://www.jto.org/cms/asset/acef0ded-e540-4a4e-8df1-364ab572d38e/gr1.jpg)
Osimertinib versus Standard of Care EGFR TKI as First-Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA Asian Subset - Journal of Thoracic Oncology
![First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) | Scientific Reports First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) | Scientific Reports](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-021-02561-z/MediaObjects/41598_2021_2561_Fig1_HTML.png)
First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) | Scientific Reports
![Landmark overall survival at 2 years and 2.5 years in patients treated... | Download Scientific Diagram Landmark overall survival at 2 years and 2.5 years in patients treated... | Download Scientific Diagram](https://www.researchgate.net/publication/328391224/figure/fig3/AS:683504220258307@1539971513793/Landmark-overall-survival-at-2-years-and-25-years-in-patients-treated-with-sequential.png)
Landmark overall survival at 2 years and 2.5 years in patients treated... | Download Scientific Diagram
![Osimertinib versus platinum–pemetrexed for patients with EGFR T790M advanced NSCLC and progression on a prior EGFR-tyrosine kinase inhibitor: AURA3 overall survival analysis - Annals of Oncology Osimertinib versus platinum–pemetrexed for patients with EGFR T790M advanced NSCLC and progression on a prior EGFR-tyrosine kinase inhibitor: AURA3 overall survival analysis - Annals of Oncology](https://www.annalsofoncology.org/cms/asset/3c519893-23a9-4078-946a-1fd1e40feff8/gr3.jpg)
Osimertinib versus platinum–pemetrexed for patients with EGFR T790M advanced NSCLC and progression on a prior EGFR-tyrosine kinase inhibitor: AURA3 overall survival analysis - Annals of Oncology
![Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study | SpringerLink Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs11523-021-00794-6/MediaObjects/11523_2021_794_Fig3_HTML.png)
Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study | SpringerLink
![Osimertinib versus Standard of Care EGFR TKI as First‐Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA Asian Subset | Semantic Scholar Osimertinib versus Standard of Care EGFR TKI as First‐Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA Asian Subset | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/f3ab934abce202c3ceaebb42bc162d49452a8f65/6-Figure2-1.png)
Osimertinib versus Standard of Care EGFR TKI as First‐Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA Asian Subset | Semantic Scholar
![Actionable Alterations - NSCLC Treatment Paradigm - Text Module - NSCLC Practical Guidance - Oncology - Clinical Care Options Actionable Alterations - NSCLC Treatment Paradigm - Text Module - NSCLC Practical Guidance - Oncology - Clinical Care Options](https://www.clinicaloptions.com/-/media/oncology/programs/nsclc-practical-guidance/module-thumbs/lung_clinical_impact_2019-20_synergy_thumb-05.png?rev=f32b2afe7cba447d87d6e3194c7ac636)
Actionable Alterations - NSCLC Treatment Paradigm - Text Module - NSCLC Practical Guidance - Oncology - Clinical Care Options
![Overall survival benefit of osimertinib and clinical value of upfront cranial local therapy in untreated EGFR‐mutant nonsmall cell lung cancer with brain metastasis - Zhao - 2022 - International Journal of Cancer - Overall survival benefit of osimertinib and clinical value of upfront cranial local therapy in untreated EGFR‐mutant nonsmall cell lung cancer with brain metastasis - Zhao - 2022 - International Journal of Cancer -](https://onlinelibrary.wiley.com/cms/asset/a92dc4fa-7935-4e34-ab67-347df8d3dacb/ijc33904-fig-0002-m.jpg)
Overall survival benefit of osimertinib and clinical value of upfront cranial local therapy in untreated EGFR‐mutant nonsmall cell lung cancer with brain metastasis - Zhao - 2022 - International Journal of Cancer -
![PDF] Patient-reported outcomes from FLAURA: Osimertinib versus erlotinib or gefitinib in patients with EGFR-mutated advanced non-small-cell lung cancer. | Semantic Scholar PDF] Patient-reported outcomes from FLAURA: Osimertinib versus erlotinib or gefitinib in patients with EGFR-mutated advanced non-small-cell lung cancer. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/95bd00058709f1a7bec951f10e9d1ada785859c9/4-Figure1-1.png)